MovDisordV3, Main, Exploration, bibRecord, 005098

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

Identifieur interne : 005098 ( Main/Exploration ); précédent : 005097; suivant : 005099

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

Auteurs : Wenning [Autriche] ; Eveline Donnemiller [Autriche] ; Roberta Granata [Autriche] ; Georg Riccabona [Autriche] ; Werner Poewe [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-05.

RBID : ISTEX:54B5ADBC320F5D46B6105637C8FE732B03C96083

English descriptors

KwdEn :
- Aged, Benzamides (diagnostic use), Carrier Proteins (physiology), Cerebellum (physiopathology), Cerebellum (radionuclide imaging), Cocaine (analogs & derivatives), Cocaine (diagnostic use), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), Dopamine Plasma Membrane Transport Proteins, Dopamine receptors, Female, Humans, IBZM, Iodine Radioisotopes (diagnostic use), Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Nerve Tissue Proteins, Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson's disease, Pyrrolidines (diagnostic use), Receptors, Dopamine D2 (physiology), SPECT imaging, Tomography, Emission-Computed, Single-Photon, β‐CIT.
MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , diagnostic use : Benzamides, Cocaine, Iodine Radioisotopes, Pyrrolidines.
- chemical , physiology : Carrier Proteins, Receptors, Dopamine D2.
- physiopathology : Cerebellum, Corpus Striatum, Parkinson Disease.
- radionuclide imaging : Cerebellum, Corpus Striatum, Parkinson Disease.
- Aged, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Nerve Tissue Proteins, Tomography, Emission-Computed, Single-Photon.

Abstract

Striatal dopamine transporter function and dopamine D2 receptor status were evaluated in 15 patients with early untreated Parkinson's disease using single photon emission tomography (SPECT) with 123I‐Iodo‐2β‐carboxymethoxy‐3β‐(4‐idiophenyl)tropane (β‐CIT) and 123I‐Iodobenzamide (IBZM) as pre‐ and postsynaptic ligands. Symptoms were unilateral in five patients and bilateral but asymmetric in 10 patients. Patients with bilateral symptoms had significantly lower 18‐hour striatal/cerebellar β‐CIT binding ratios (3.59 ± 0.79) than hemiparkinsonian patients (5.76 ± 1.48, p < 0.05) reflecting more advanced disease in this subgroup. Patients with bilateral parkinsonism were also found to have a significant side‐to‐side difference in striatal β‐CIT binding with more marked reduction contralateral to the presenting limb (18‐hour striatal/cerebellar ratio: 4.13 ± 0.78 [ipsilateral] versus 3.59 ± 0.79 [contralateral], p < 0.05). Dopamine D2 receptor binding as measured by IBZM was significantly elevated contralateral to the affected side in hemiparkinsonian patients (striatal/cerebellar ratio: 2.42 ± 0.90 [contralateral] versus 2.19 ± 0.80 [ipsilateral], p < 0.05). This asymmetric upregulation was absent in the patients with bilateral parkinsonism (striatal/cerebellar ratio: 1.85 ± 0.43 [contralateral to more severely affected side] versus 1.83 ± 0.34 [ipsilateral], p > 0.05). Our data suggest that postsynaptic dopamine receptor upregulation contralateral to the presenting side occurs in untreated unilateral PD and disappears in untreated bilateral (asymmetric) PD despite a greater loss of dopamine transporter function. Combined β‐CIT and IBZM SPECT studies may be helpful to monitor the progression of nigrostriatal dysfunction in early PD.

Url:

https://api.istex.fr/document/54B5ADBC320F5D46B6105637C8FE732B03C96083/fulltext/pdf

DOI: 10.1002/mds.870130311

Affiliations:

Le document en format XML

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<term>Benzamides (diagnostic use)</term>
<term>Carrier Proteins (physiology)</term>
<term>Cerebellum (physiopathology)</term>
<term>Cerebellum (radionuclide imaging)</term>
<term>Cocaine (analogs & derivatives)</term>
<term>Cocaine (diagnostic use)</term>
<term>Corpus Striatum (physiopathology)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Dopamine receptors</term>
<term>Female</term>
<term>Humans</term>
<term>IBZM</term>
<term>Iodine Radioisotopes (diagnostic use)</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson's disease</term>
<term>Pyrrolidines (diagnostic use)</term>
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<term>SPECT imaging</term>
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<term>Humans</term>
<term>Male</term>
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<term>Membrane Transport Proteins</term>
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<term>Nerve Tissue Proteins</term>
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<front><div type="abstract" xml:lang="en">Striatal dopamine transporter function and dopamine D2 receptor status were evaluated in 15 patients with early untreated Parkinson's disease using single photon emission tomography (SPECT) with 123I‐Iodo‐2β‐carboxymethoxy‐3β‐(4‐idiophenyl)tropane (β‐CIT) and 123I‐Iodobenzamide (IBZM) as pre‐ and postsynaptic ligands. Symptoms were unilateral in five patients and bilateral but asymmetric in 10 patients. Patients with bilateral symptoms had significantly lower 18‐hour striatal/cerebellar β‐CIT binding ratios (3.59 ± 0.79) than hemiparkinsonian patients (5.76 ± 1.48, p < 0.05) reflecting more advanced disease in this subgroup. Patients with bilateral parkinsonism were also found to have a significant side‐to‐side difference in striatal β‐CIT binding with more marked reduction contralateral to the presenting limb (18‐hour striatal/cerebellar ratio: 4.13 ± 0.78 [ipsilateral] versus 3.59 ± 0.79 [contralateral], p < 0.05). Dopamine D2 receptor binding as measured by IBZM was significantly elevated contralateral to the affected side in hemiparkinsonian patients (striatal/cerebellar ratio: 2.42 ± 0.90 [contralateral] versus 2.19 ± 0.80 [ipsilateral], p < 0.05). This asymmetric upregulation was absent in the patients with bilateral parkinsonism (striatal/cerebellar ratio: 1.85 ± 0.43 [contralateral to more severely affected side] versus 1.83 ± 0.34 [ipsilateral], p > 0.05). Our data suggest that postsynaptic dopamine receptor upregulation contralateral to the presenting side occurs in untreated unilateral PD and disappears in untreated bilateral (asymmetric) PD despite a greater loss of dopamine transporter function. Combined β‐CIT and IBZM SPECT studies may be helpful to monitor the progression of nigrostriatal dysfunction in early PD.</div>
</front>
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Movement Disorders (revue)

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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	Movement Disorders (revue)
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